金沙威尼斯欢乐娱人城
2012学年秋季学期系列学术讲座之十二
题目：Bistability and trigger waves in mitosis
报告人：James Ferrell
Professor of Chemical and Systems Biology;
Professor of Biochemistry,
Stanford University School of Medicine
时间：2012年12月7日（周五），13:00-14:30 PM
地点：金沙威尼斯欢乐娱人城一楼邓祐才报告厅
The Xenopus early embryonic cell cycle is driven by oscillations in the concentration of cyclin B and in the activity of cyclin B-Cdk1 complexes. We have been studying the Cdk1 oscillator through quantitative experiments and computational modeling. Here we show that the oscillator circuit includes a bistable trigger, built out of interlinked positive and double-negative feedback loops. This trigger allows the Cdk1 circuit to generate rapidly propagating waves of Cdk1 activation and inactivation, which help to keep mitosis coordinated over the large distance scales (~mm) of the frog egg.
Selected Publications:
1. Santos SDM, Wollman R, Meyer T, Ferrell JE Jr. (2012). Spatial positive feedback at the onset of mitosis. Cell 149:1500-1513.
2. Ferrell JE Jr. (2012). Bistability, bifurcations, and Waddington`s epigenetic landscape. Curr Biol 22:R458-R466.
3. Pearlman SM, Serber Z, Ferrell JE Jr. (2011). A mechanism for the evolution of phosphorylation sites. Cell, 147:934-946.
4. Trunnell NB, Poon AC, Kim SY, Ferrell JE Jr. (2011) Ultrasensitivity in the regulation of Cdc25C by Cdk1. Mol Cell, 41:263-274.
联系人：汤超（电话：62759711）
欢迎各位老师和同学积极参加！