金沙威尼斯欢乐娱人城
2013学年春季学期系列学术讲座之十一
题目：The Hippo-YAP pathway in cell growth, organ size, and tumorigenesis
报告人：Kunliang Guan
Professor, Department of Pharmacology,
Member, Moores Cancer Center, University of California, San Diego
时间：2013年5月31日（周五），下午13:00-14:30 PM
地点：金沙威尼斯欢乐娱人城一楼邓祐才报告厅
Abstract:
The Hippo pathway is crucial in organ size control and its dysregulation contributes to tumorigenesis. This pathway is regulated by cell density and plays a critical role in cell contact inhibition. Our recent studies demonstrate that the Hippo pathway is regulated by G-protein coupled receptor (GPCR) signaling, which can either activate or inhibit the Hippo-YAP pathway in a manner depending on the coupled G-proteins. The cross talk between Hippo and other intracellular signaling pathways will be discussed. Our study identifies extracellular diffusible signals that modulate the Hippo pathway activity and also establishes the Hippo-YAP pathway as a critical signaling branch downstream of GPCR.
联系人：饶毅（电话：62751850）
欢迎各位老师和同学积极参加！