金沙威尼斯欢乐娱人城2015年度春季学期学术系列讲座之七

题目：Nutritional control of neural stem cell quiescence and reactivation

讲座人：Andrea H Brand, Ph.D.

Herchel Smith Professor of Molecular Biology

Department of Physiology, Development and Neuroscience

The Gurdon Institute

University of Cambridge

Fellow of the Royal Society of London

时间：2015年5月8日，13:00-14:30pm

地点：邓祐才报告厅

联系人：宋艳

The systemic regulation of stem cells ensures they meet the needs of the organism during growth and in response to injury.  A key control point is the decision between quiescence and proliferation.  Drosophila neural stem cells (NSCs) enter quiescence in late embryogenesis and are reactivated post-embryonically in response to a nutrition-dependent signal from the fat body.  We identified a population of glial cells that overlie NSCs and secrete Insulin/IGF-like peptides locally in response to nutrition.  We found that insulin signalling is essential for NSCs to exit quiescence.  Insulin signalling can also promote proliferation in vertebrate neural stem cells, suggesting that the mechanisms controlling stem cell reactivation may be conserved.  We are investigating the systemic and local signals that regulate neural stem cell quiescence and reactivation.

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