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Exogenous artificial DNA forms chromatin structure with active transcription in yeast

A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation

Quantitative model suggests both intrinsic and contextual features contribute to the transcript coding ability determination in cells

Structure, function and pharmacology of human itch receptor complexes

A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo

Noncoding loci without epigenomic signals can be essential for maintaining global chromatin organization and cell viability

Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection

Increasing the efficiency and precision of prime editing with guide RNA pairs

RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombination

T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese

PmiREN2.0: from data annotation to functional exploration of plant microRNAs

Prey partitioning and livestock consumption in the world’s richest large carnivore assemblage

Structural insight into the mechanism of energy transfer in cyanobacterial phycobilisomes

The genetics and evolution of eye color in domestic pigeons (Columba livia)

Generalist carnivores can be effective biodiversity samplers of terrestrial vertebrates

Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants

Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry

A body map of somatic mutagenesis in morphologically normal human tissues

In-depth assessment of the PAM compatibility and editing activities of Cas9 variants